Radioligand Therapy Target Profiles
Evidence profiles for radioligand therapy targets: localization, tumor expression across 20 cancers, internalization, shedding, clinical trials and gene essentiality, all in one place.
Featured targets
PSMA (FOLH1) SSTR2 HER2 (ERBB2) HER3 (ERBB3) CEA (CEACAM5) TROP2 (TACSTD2) Nectin-4 (NECTIN4) Mesothelin (MSLN) CAIX (CA9) Claudin 18.2 (CLDN18) B7-H3 (CD276) CD20 (MS4A1) BCMA (TNFRSF17) FRα (FOLR1) CCK2R (CCKBR) c-MET (MET)
Browse by cancer type
Prostate Cancer Neuroendocrine Tumors Lung Cancer Pancreatic Cancer Breast Cancer Ovarian Cancer Colorectal Cancer Kidney Cancer Bladder Cancer Gastric Cancer Liver Cancer Glioma Melanoma Head and Neck Cancer Thyroid Cancer Lymphoma Cervical Cancer Endometrial Cancer Skin Cancer Testicular Cancer
All targets A–Z
A
ABL1 ADAM23 ADGRL1 ADGRL3 ADRA2C ADRM1 AGER AGTRAP ALK AMDHD1 AMFR APLNR APOLD1 ARHGAP23 ASGR1 ASTN2 ATAD3B ATP6AP2 ATP6V1A AXIN2
B
B3GAT2 BAALC BCL2L2-PABPN1 BDH1 BIN1
C
C2CD5 C7 CA9 CALCRL CASR CCKBR CCND2 CCRL2 CD19 CD22 CD276 CD33 CD38 CD3G CD70 CDK2 CDK4 CEACAM5 CFB CHRM1 CHRM2 CHRNA4 CHRNA7 CLDN18 CLDN3 CLIP2 CLU CNR1 CNR2 CNTFR COL23A1 CPAMD8 CREB3L1 CREB3L4 CSPG4 CTNNB1 CTSB CXCR4 CYP1A1 CYRIA CYSLTR2
D
E
EDNRB EGFR EMCN EPCAM EPHA3 EPHA4 EPHA7 EPHA8 EPHB2 EPHB4 ERBB2 ERBB3 ERBB4 ESR1 EVC
F
F2RL1 FAAH FADS2 FAM161B FAP FGFR1 FGFR3 FGFR4 FLT1 FLT4 FMN1 FNIP2 FOLH1 FOLR1 FYN FZD3 FZD5 FZD6
G
GAB2 GABRE GABRG3 GABRP GAS1 GCNT3 GFRA1 GFRA3 GJB1 GLP1R GOLM1 GPC3 GPER1 GPR139 GPR143 GPR34 GPR37 GPR4 GRIK1 GRIK2 GRK6 GRPR GSDME
H
HAPLN3 HAVCR2 HCAR2 HEPH HILPDA HMGA1 HOMER2 HRH4 HSD17B6 HTR3A HTR3B HTR6
I
IGF1R IL1R2 IL3RA IRAK4 ITGAV ITGB6 ITGB8 ITM2B ITPR3
K
KCNC2 KCND3 KCNG1 KCNIP1 KCNQ1 KISS1R KIT KLB KLHL14 KSR1
L
LDB2 LEPR LGR5 LHCGR LIFR LPAR5 LPCAT1 LRP1B LRP4 LSR LTB4R2 LZTS1
M
M6PR MAD1L1 MAOB MC1R MCAM MEP1A MET MFGE8 MFSD12 MMP10 MRNIP MS4A1 MSLN MST1R MTSS1 MUC16
N
NECTIN4 NGEF NNT NOTCH1 NOTCH2 NOTCH3 NR3C2 NRP1 NTRK2 NTRK3 NTSR1
O
P
P2RX7 PCDHGC3 PDE4B PDE9A PDGFRA PDLIM5 PGR PKD1L1 PLA2G2A PLA2G5 PLCG2 PLPP3 PNCK PNPLA7 PON2 PSCA PTGER4 PTGS1 PTGS2 PTPN13 PTPN22 PTPRB PTPRC PTPRN PXK
R
RAB15 RASSF2 REEP6 RET RGMA RGS6 RHOH RNF43 ROBO2 ROS1
S
S1PR1 SCHIP1 SCN9A SCNN1A SCNN1B SCTR SDC3 SDCBP SEMA6A SLC12A2 SLC22A17 SLC22A3 SLC34A2 SLC39A6 SLC44A4 SLC6A9 SLC7A5 SLITRK6 SMOC1 SMOX SSTR1 SSTR2 SSTR3 SSTR5 ST3GAL1 STEAP1 STEAP2 SUSD2 SV2A SYTL1
T
TAAR1 TACSTD2 TCIM TEK TENM2 TFR2 TFRC TGFA TIAM1 TLR3 TMEFF2 TMEM176B TNFRSF13C TNFRSF17 TNFRSF1A TNFRSF8 TPST1 TRABD2A TREM1 TREM2 TRIM71 TRPC6 TRPV2 TSHR TYRP1
V
Z
Data sources
Subcellular localization: UniProt via Open Targets (CC BY 4.0 / CC0). Tumor immunohistochemistry: Human Protein Atlas (CC BY-SA 4.0). Clinical trials: ClinicalTrials.gov (public domain). Gene essentiality: DepMap (CC BY 4.0). Internalization and shedding: AI-extracted from PubMed abstracts, so verify against the cited papers before relying on them. Nuclens is a first-pass triage layer, not a substitute for wet-lab validation or clinical dosimetry. Derived expression data on this page is shared under CC BY-SA 4.0.