SDCBP as a Radioligand Therapy Target
SDCBP, syndecan binding protein, is a cell-surface protein. In Human Protein Atlas immunohistochemistry, SDCBP staining is highest in melanoma (100% of samples positive), colorectal cancer (100% of samples positive) and endometrial cancer (100% of samples positive). Clinical status: Discovery-stage (no clinical drug program).
Is SDCBP a good radioligand therapy target?
Scored against the six criteria that decide whether a protein can become a radioligand therapy:
- ✅ Cell-surface accessibility: Localized to the cell surface, so a radioligand can reach it from circulation.
- ✅ Tumor expression: High IHC staining in melanoma, 100% of samples positive.
- ❔ Internalization: Not yet assessed.
- ⚠️ Clinical precedent: Discovery-stage (no clinical drug program)
- ❔ Shedding: Not yet assessed.
- ❔ Normal-tissue dosimetry: Check kidney, liver, bone marrow and salivary expression in the Human Protein Atlas tissue atlas.
SDCBP expression in cancer
Protein expression of SDCBP across 20 cancer types from Human Protein Atlas immunohistochemistry. The score is a weighted staining intensity from 0 to 1; "% positive" is the share of patient samples with detectable staining.
| Cancer type | IHC score | Level | % positive |
|---|---|---|---|
| Melanoma | 1.00 | High | 100% |
| Colorectal Cancer | 0.78 | High | 100% |
| Endometrial Cancer | 0.70 | High | 100% |
| Prostate Cancer | 0.67 | High | 100% |
| Head and Neck Cancer | 0.58 | High | 100% |
| Testicular Cancer | 0.58 | High | 91% |
| Ovarian Cancer | 0.52 | High | 91% |
| Lung Cancer | 0.50 | Medium | 90% |
| Breast Cancer | 0.44 | Medium | 83% |
| Liver Cancer | 0.42 | Medium | 83% |
| Cervical Cancer | 0.36 | Medium | 75% |
| Pancreatic Cancer | 0.30 | Medium | 82% |
| Bladder Cancer | 0.28 | Medium | 50% |
| Gastric Cancer | 0.27 | Medium | 70% |
| Thyroid Cancer | 0.25 | Medium | 75% |
| Neuroendocrine Tumors | 0.25 | Medium | 75% |
| Skin Cancer | 0.22 | Medium | 58% |
| Kidney Cancer | 0.21 | Medium | 46% |
| Lymphoma | 0.17 | Low | 42% |
| Glioma | 0.08 | Low | 25% |
Is SDCBP internalized?
Nuclens has not yet extracted internalization evidence for SDCBP. Internalization matters for radioligands because an internalizing receptor traps the radionuclide inside the tumor cell. Run a full analysis to pull the latest literature.
SDCBP clinical trials
Discovery-stage (no clinical drug program). Nuclens hasn't indexed trials for SDCBP yet. Search ClinicalTrials.gov for SDCBP trials.
SDCBP normal tissue expression
Normal-tissue expression in dose-limiting organs (kidney, liver, bone marrow, salivary glands) drives radioligand dosimetry risk. Nuclens is re-validating its normal-tissue values, so they are not shown here yet. See SDCBP in the Human Protein Atlas tissue atlas, and read how normal-tissue expression predicts radioligand dosimetry risk.
SDCBP gene essentiality (DepMap)
CRISPR knockout effect across 1258 cancer cell lines: -0.07 (not essential). Radioligands kill by radiation, not by blocking the target, so essentiality matters less than for inhibitors. A non-essential target can still be an excellent radioligand target.
Related melanoma radioligand targets
HER3 (ERBB3) · c-MET (MET) · STEAP2 · SSTR2 · B7-H3 (CD276) · ITGAV · TMEFF2 · FAP
See all radioligand therapy targets in melanoma.
See how SDCBP ranks against 15,000 targets for your indication.
Run a free analysisData sources
Subcellular localization: UniProt via Open Targets (CC BY 4.0 / CC0). Tumor immunohistochemistry: Human Protein Atlas (CC BY-SA 4.0). Clinical trials: ClinicalTrials.gov (public domain). Gene essentiality: DepMap (CC BY 4.0). Internalization and shedding: AI-extracted from PubMed abstracts, so verify against the cited papers before relying on them. Nuclens is a first-pass triage layer, not a substitute for wet-lab validation or clinical dosimetry. Derived expression data on this page is shared under CC BY-SA 4.0.