ATAD3B as a Radioligand Therapy Target
ATAD3B, ATPase family AAA domain containing 3B, is a cell-surface protein. In Human Protein Atlas immunohistochemistry, ATAD3B staining is highest in colorectal cancer (100% of samples positive), gastric cancer (100% of samples positive) and testicular cancer (100% of samples positive). Clinical status: Discovery-stage (no clinical drug program).
Is ATAD3B a good radioligand therapy target?
Scored against the six criteria that decide whether a protein can become a radioligand therapy:
- ✅ Cell-surface accessibility: Localized to the cell surface, so a radioligand can reach it from circulation.
- ✅ Tumor expression: High IHC staining in colorectal cancer, 100% of samples positive.
- ❔ Internalization: Not yet assessed.
- ⚠️ Clinical precedent: Discovery-stage (no clinical drug program)
- ❔ Shedding: Not yet assessed.
- ❔ Normal-tissue dosimetry: Check kidney, liver, bone marrow and salivary expression in the Human Protein Atlas tissue atlas.
ATAD3B expression in cancer
Protein expression of ATAD3B across 20 cancer types from Human Protein Atlas immunohistochemistry. The score is a weighted staining intensity from 0 to 1; "% positive" is the share of patient samples with detectable staining.
| Cancer type | IHC score | Level | % positive |
|---|---|---|---|
| Colorectal Cancer | 1.00 | High | 100% |
| Gastric Cancer | 1.00 | High | 100% |
| Testicular Cancer | 0.97 | High | 100% |
| Cervical Cancer | 0.97 | High | 100% |
| Pancreatic Cancer | 0.96 | High | 100% |
| Ovarian Cancer | 0.94 | High | 100% |
| Melanoma | 0.94 | High | 100% |
| Lung Cancer | 0.94 | High | 100% |
| Head and Neck Cancer | 0.92 | High | 100% |
| Bladder Cancer | 0.92 | High | 100% |
| Liver Cancer | 0.85 | High | 100% |
| Thyroid Cancer | 0.83 | High | 100% |
| Neuroendocrine Tumors | 0.83 | High | 100% |
| Prostate Cancer | 0.83 | High | 100% |
| Glioma | 0.83 | High | 100% |
| Breast Cancer | 0.80 | High | 100% |
| Endometrial Cancer | 0.80 | High | 100% |
| Skin Cancer | 0.73 | High | 91% |
| Lymphoma | 0.70 | High | 73% |
| Kidney Cancer | 0.47 | Medium | 75% |
Is ATAD3B internalized?
Nuclens has not yet extracted internalization evidence for ATAD3B. Internalization matters for radioligands because an internalizing receptor traps the radionuclide inside the tumor cell. Run a full analysis to pull the latest literature.
ATAD3B clinical trials
Discovery-stage (no clinical drug program). Nuclens hasn't indexed trials for ATAD3B yet. Search ClinicalTrials.gov for ATAD3B trials.
ATAD3B normal tissue expression
Normal-tissue expression in dose-limiting organs (kidney, liver, bone marrow, salivary glands) drives radioligand dosimetry risk. Nuclens is re-validating its normal-tissue values, so they are not shown here yet. See ATAD3B in the Human Protein Atlas tissue atlas, and read how normal-tissue expression predicts radioligand dosimetry risk.
ATAD3B gene essentiality (DepMap)
CRISPR knockout effect across 1258 cancer cell lines: -0.05 (not essential). Radioligands kill by radiation, not by blocking the target, so essentiality matters less than for inhibitors. A non-essential target can still be an excellent radioligand target.
Related colorectal cancer radioligand targets
c-MET (MET) · HER3 (ERBB3) · FAP · EGFR · CEA (CEACAM5) · EPCAM · SSTR2 · STEAP2
See all radioligand therapy targets in colorectal cancer.
See how ATAD3B ranks against 15,000 targets for your indication.
Run a free analysisData sources
Subcellular localization: UniProt via Open Targets (CC BY 4.0 / CC0). Tumor immunohistochemistry: Human Protein Atlas (CC BY-SA 4.0). Clinical trials: ClinicalTrials.gov (public domain). Gene essentiality: DepMap (CC BY 4.0). Internalization and shedding: AI-extracted from PubMed abstracts, so verify against the cited papers before relying on them. Nuclens is a first-pass triage layer, not a substitute for wet-lab validation or clinical dosimetry. Derived expression data on this page is shared under CC BY-SA 4.0.