TYRP1 as a Radioligand Therapy Target
TYRP1, tyrosinase related protein 1, is a cell-surface protein. In Human Protein Atlas immunohistochemistry, TYRP1 staining is highest in melanoma (80% of samples positive), colorectal cancer (46% of samples positive) and head and neck cancer (33% of samples positive). Clinical status: Clinical-stage (up to phase 1, any modality).
Is TYRP1 a good radioligand therapy target?
Scored against the six criteria that decide whether a protein can become a radioligand therapy:
- ✅ Cell-surface accessibility: Localized to the cell surface, so a radioligand can reach it from circulation.
- ✅ Tumor expression: High IHC staining in melanoma, 80% of samples positive.
- ❔ Internalization: Not yet assessed.
- ✅ Clinical precedent: Clinical-stage (up to phase 1, any modality)
- ❔ Shedding: Not yet assessed.
- ❔ Normal-tissue dosimetry: Check kidney, liver, bone marrow and salivary expression in the Human Protein Atlas tissue atlas.
TYRP1 expression in cancer
Protein expression of TYRP1 across 20 cancer types from Human Protein Atlas immunohistochemistry. The score is a weighted staining intensity from 0 to 1; "% positive" is the share of patient samples with detectable staining.
| Cancer type | IHC score | Level | % positive |
|---|---|---|---|
| Melanoma | 0.67 | High | 80% |
| Colorectal Cancer | 0.15 | Low | 46% |
| Head and Neck Cancer | 0.11 | Low | 33% |
| Testicular Cancer | 0.11 | Low | 33% |
| Skin Cancer | 0.10 | Low | 30% |
| Lymphoma | 0.08 | Low | 17% |
| Bladder Cancer | 0.06 | Low | 17% |
| Liver Cancer | 0.04 | Low | 11% |
Not detected by IHC in: ovarian cancer, breast cancer, kidney cancer, thyroid cancer, neuroendocrine tumors, cervical cancer, lung cancer, pancreatic cancer, prostate cancer, gastric cancer, endometrial cancer, glioma.
Is TYRP1 internalized?
Nuclens has not yet extracted internalization evidence for TYRP1. Internalization matters for radioligands because an internalizing receptor traps the radionuclide inside the tumor cell. Run a full analysis to pull the latest literature.
TYRP1 clinical trials
Clinical-stage (up to phase 1, any modality). Nuclens hasn't indexed trials for TYRP1 yet. Search ClinicalTrials.gov for TYRP1 trials.
TYRP1 normal tissue expression
Normal-tissue expression in dose-limiting organs (kidney, liver, bone marrow, salivary glands) drives radioligand dosimetry risk. Nuclens is re-validating its normal-tissue values, so they are not shown here yet. See TYRP1 in the Human Protein Atlas tissue atlas, and read how normal-tissue expression predicts radioligand dosimetry risk.
TYRP1 gene essentiality (DepMap)
CRISPR knockout effect across 1256 cancer cell lines: -0.03 (not essential). Radioligands kill by radiation, not by blocking the target, so essentiality matters less than for inhibitors. A non-essential target can still be an excellent radioligand target.
Related melanoma radioligand targets
HER3 (ERBB3) · c-MET (MET) · STEAP2 · SSTR2 · B7-H3 (CD276) · ITGAV · TMEFF2 · FAP
See all radioligand therapy targets in melanoma.
See how TYRP1 ranks against 15,000 targets for your indication.
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Subcellular localization: UniProt via Open Targets (CC BY 4.0 / CC0). Tumor immunohistochemistry: Human Protein Atlas (CC BY-SA 4.0). Clinical trials: ClinicalTrials.gov (public domain). Gene essentiality: DepMap (CC BY 4.0). Internalization and shedding: AI-extracted from PubMed abstracts, so verify against the cited papers before relying on them. Nuclens is a first-pass triage layer, not a substitute for wet-lab validation or clinical dosimetry. Derived expression data on this page is shared under CC BY-SA 4.0.