KCNG1 as a Radioligand Therapy Target
KCNG1, potassium voltage-gated channel modifier subfamily G member 1, is a cell-surface protein. In Human Protein Atlas immunohistochemistry, KCNG1 staining is highest in endometrial cancer (100% of samples positive), ovarian cancer (100% of samples positive) and colorectal cancer (100% of samples positive). Clinical status: Clinical-stage (up to phase 2, any modality).
Is KCNG1 a good radioligand therapy target?
Scored against the six criteria that decide whether a protein can become a radioligand therapy:
- ✅ Cell-surface accessibility: Localized to the cell surface, so a radioligand can reach it from circulation.
- ✅ Tumor expression: High IHC staining in endometrial cancer, 100% of samples positive.
- ❔ Internalization: Not yet assessed.
- ✅ Clinical precedent: Clinical-stage (up to phase 2, any modality)
- ❔ Shedding: Not yet assessed.
- ❔ Normal-tissue dosimetry: Check kidney, liver, bone marrow and salivary expression in the Human Protein Atlas tissue atlas.
KCNG1 expression in cancer
Protein expression of KCNG1 across 20 cancer types from Human Protein Atlas immunohistochemistry. The score is a weighted staining intensity from 0 to 1; "% positive" is the share of patient samples with detectable staining.
| Cancer type | IHC score | Level | % positive |
|---|---|---|---|
| Endometrial Cancer | 0.94 | High | 100% |
| Ovarian Cancer | 0.89 | High | 100% |
| Colorectal Cancer | 0.81 | High | 100% |
| Thyroid Cancer | 0.78 | High | 100% |
| Lung Cancer | 0.77 | High | 100% |
| Liver Cancer | 0.77 | High | 100% |
| Lymphoma | 0.75 | High | 100% |
| Prostate Cancer | 0.75 | High | 100% |
| Bladder Cancer | 0.73 | High | 100% |
| Breast Cancer | 0.73 | High | 100% |
| Melanoma | 0.73 | High | 100% |
| Gastric Cancer | 0.71 | High | 100% |
| Neuroendocrine Tumors | 0.67 | High | 100% |
| Kidney Cancer | 0.63 | High | 90% |
| Pancreatic Cancer | 0.63 | High | 89% |
| Testicular Cancer | 0.63 | High | 100% |
| Cervical Cancer | 0.58 | High | 91% |
| Skin Cancer | 0.52 | High | 82% |
| Head and Neck Cancer | 0.50 | Medium | 100% |
| Glioma | 0.38 | Medium | 88% |
Is KCNG1 internalized?
Nuclens has not yet extracted internalization evidence for KCNG1. Internalization matters for radioligands because an internalizing receptor traps the radionuclide inside the tumor cell. Run a full analysis to pull the latest literature.
KCNG1 clinical trials
Clinical-stage (up to phase 2, any modality). Nuclens hasn't indexed trials for KCNG1 yet. Search ClinicalTrials.gov for KCNG1 trials.
KCNG1 normal tissue expression
Normal-tissue expression in dose-limiting organs (kidney, liver, bone marrow, salivary glands) drives radioligand dosimetry risk. Nuclens is re-validating its normal-tissue values, so they are not shown here yet. See KCNG1 in the Human Protein Atlas tissue atlas, and read how normal-tissue expression predicts radioligand dosimetry risk.
KCNG1 gene essentiality (DepMap)
CRISPR knockout effect across 1255 cancer cell lines: -0.11 (not essential). Radioligands kill by radiation, not by blocking the target, so essentiality matters less than for inhibitors. A non-essential target can still be an excellent radioligand target.
Related endometrial cancer radioligand targets
HER3 (ERBB3) · c-MET (MET) · EGFR · EPCAM · B7-H3 (CD276) · SSTR2 · ITGAV · STEAP2
See all radioligand therapy targets in endometrial cancer.
See how KCNG1 ranks against 15,000 targets for your indication.
Run a free analysisData sources
Subcellular localization: UniProt via Open Targets (CC BY 4.0 / CC0). Tumor immunohistochemistry: Human Protein Atlas (CC BY-SA 4.0). Clinical trials: ClinicalTrials.gov (public domain). Gene essentiality: DepMap (CC BY 4.0). Internalization and shedding: AI-extracted from PubMed abstracts, so verify against the cited papers before relying on them. Nuclens is a first-pass triage layer, not a substitute for wet-lab validation or clinical dosimetry. Derived expression data on this page is shared under CC BY-SA 4.0.